|Other Names||Proprotein convertase subtilisin/kexin type 7, 3421-, Lymphoma proprotein convertase, Prohormone convertase 7, Proprotein convertase 7, PC7, Proprotein convertase 8, PC8, hPC8, Subtilisin/kexin-like protease PC7, PCSK7, LPC, PC7, PC8, SPC7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14045b was selected from the C-term region of PCSK7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||LPC, PC7, PC8, SPC7|
|Function||Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Seems to be localized intracellularly to the trans Golgi network.|
|Tissue Location||Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to thesubtilisin-like proprotein convertase family. The members of thisfamily are proprotein convertases that process latent precursorproteins into their biologically active products. This encodedprotein is a calcium-dependent serine endoprotease. It isstructurally related to its family members, PACE and PACE4. Thisprotein is concentrated in the trans-Golgi network, associated withthe membranes, and is not secreted. It can process proalbumin andis thought to be responsible for the activation of HIV envelopeglycoproteins gp160 and gp140. This gene has been implicated in thetranscriptional regulation of housekeeping genes. Multiplealternatively spliced transcripts are described for this gene buttheir full length nature is not yet known. Downstream of thisgene's map location at 11q23-q24, nucleotides that match part ofthis gene's 3' end are duplicated and inverted. A translocationbreakpoint associated with lymphoma occurs between this gene andits inverted counterpart.
Leonhardt, R.M., et al. J. Immunol. 184(6):2985-2998(2010)McColl, B.K., et al. FASEB J. 21(4):1088-1098(2007)Bruzzaniti, A., et al. Peptides 23(5):863-875(2002)Fugere, M., et al. J. Biol. Chem. 277(10):7648-7656(2002)Pearton, D.J., et al. Exp. Dermatol. 10(3):193-203(2001)
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