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PCSK7 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q16549
Clone Names 100430338
Peptide ID 100430338
Additional Information
Gene ID 9159
Other Names Proprotein convertase subtilisin/kexin type 7, 3421-, Lymphoma proprotein convertase, Prohormone convertase 7, Proprotein convertase 7, PC7, Proprotein convertase 8, PC8, hPC8, Subtilisin/kexin-like protease PC7, PCSK7, LPC, PC7, PC8, SPC7
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14045b was selected from the C-term region of PCSK7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCSK7
Synonyms LPC, PC7, PC8, SPC7
Function Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif.
Cellular Location Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Seems to be localized intracellularly to the trans Golgi network.
Tissue Location Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte
Research Areas
Citations (0)

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The protein encoded by this gene belongs to thesubtilisin-like proprotein convertase family. The members of thisfamily are proprotein convertases that process latent precursorproteins into their biologically active products. This encodedprotein is a calcium-dependent serine endoprotease. It isstructurally related to its family members, PACE and PACE4. Thisprotein is concentrated in the trans-Golgi network, associated withthe membranes, and is not secreted. It can process proalbumin andis thought to be responsible for the activation of HIV envelopeglycoproteins gp160 and gp140. This gene has been implicated in thetranscriptional regulation of housekeeping genes. Multiplealternatively spliced transcripts are described for this gene buttheir full length nature is not yet known. Downstream of thisgene's map location at 11q23-q24, nucleotides that match part ofthis gene's 3' end are duplicated and inverted. A translocationbreakpoint associated with lymphoma occurs between this gene andits inverted counterpart.


Leonhardt, R.M., et al. J. Immunol. 184(6):2985-2998(2010)McColl, B.K., et al. FASEB J. 21(4):1088-1098(2007)Bruzzaniti, A., et al. Peptides 23(5):863-875(2002)Fugere, M., et al. J. Biol. Chem. 277(10):7648-7656(2002)Pearton, D.J., et al. Exp. Dermatol. 10(3):193-203(2001)

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$ 80.00
Cat# BP14045b
Availability: In Stock
Bulk Size
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