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NRD1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43847 |
|---|---|
| Clone Names | 100507021 |
| Gene ID | 4898 |
|---|---|
| Other Names | Nardilysin, N-arginine dibasic convertase, NRD convertase, NRD-C, NRD1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14048c was selected from the Center region of NRD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NRDC (HGNC:7995) |
|---|---|
| Synonyms | NRD1 |
| Function | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). |
| Cellular Location | Mitochondrion. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHG1} |
| Tissue Location | Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NRD1 cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
References
Korovkina, V.P., et al. Am. J. Physiol., Cell Physiol. 296 (3), C433-C440 (2009) :Hiraoka, Y., et al. Biochem. Biophys. Res. Commun. 370(1):154-158(2008)Bernstein, H.G., et al. Neuroscience 146(4):1513-1523(2007)Nishi, E., et al. J. Biol. Chem. 281(41):31164-31172(2006)Hospital, V., et al. Protein Pept. Lett. 11(5):501-508(2004)
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