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Synthetic peptide
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| Primary Accession | Q9GZV4 |
|---|---|
| Clone Names | 100507031 |
| Peptide ID | 100507031 |
| Gene ID | 56648 |
|---|---|
| Other Names | Eukaryotic translation initiation factor 5A-2, eIF-5A-2, eIF-5A2, Eukaryotic initiation factor 5A isoform 2, EIF5A2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14052b was selected from the C-term region of EIF5A2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EIF5A2 |
|---|---|
| Function | mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. |
| Tissue Location | Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis Overexpressed in some cancer cells. |
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Background
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).
References
Tang, D.J., et al. Hepatology 51(4):1255-1263(2010)Luo, J.H., et al. Cancer Sci. 100(5):896-902(2009)Chen, W., et al. Cancer Epidemiol. Biomarkers Prev. 18(2):400-408(2009)Yang, G.F., et al. Gynecol. Oncol. 112(2):314-318(2009)Xie, D., et al. Hum. Pathol. 39(1):80-86(2008)
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