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RORB Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q92753
Clone Names 100507036
Peptide ID 100507036
Additional Information
Other Names Nuclear receptor ROR-beta, Nuclear receptor RZR-beta, Nuclear receptor subfamily 1 group F member 2, Retinoid-related orphan receptor-beta, RORB, NR1F2, RZRB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14054b was selected from the C-term region of RORB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NR1F2, RZRB
Function Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the NR1subfamily of nuclear hormone receptors. It is a DNA-binding proteinthat can bind as a monomer or as a homodimer to hormone responseelements upstream of several genes to enhance the expression ofthose genes. The specific functions of this protein are not known,but it has been shown to interact with NM23-2, a nucleosidediphosphate kinase involved in organogenesis and differentiation.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Mansour, H.A., et al. Bipolar Disord 11(7):701-710(2009)McGrath, C.L., et al. BMC Psychiatry 9, 70 (2009) :Humphray, S.J., et al. Nature 429(6990):369-374(2004)

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$ 80.00
Cat# BP14054b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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