|Other Names||Neurturin, NRTN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14055c was selected from the Center region of NRTN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.|
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Neurturin is a member of the TGF-beta subfamily, TRN. Thisgene signals through RET and a GPI-linked coreceptor, and promotessurvival of neuronal populations. A neurturin mutation has beendescribed in a family with Hirschsprung Disease. [provided byRefSeq].
Fernandez, R.M., et al. J. Pediatr. Surg. 43(11):2042-2047(2008)Adly, M.A., et al. J. Am. Acad. Dermatol. 58(2):238-250(2008)Yoong, L.F., et al. J. Neurosci. 27(21):5603-5614(2007)Yoong, L.F., et al. J. Neurochem. 98(4):1149-1158(2006)Vargas-Leal, V., et al. J. Immunol. 175(4):2301-2308(2005)
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