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CIDEA Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O60543
Clone Names 100507042
Peptide ID 100507042
Additional Information
Gene ID 1149
Other Names Cell death activator CIDE-A, Cell death-inducing DFFA-like effector A, CIDEA
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14057b was selected from the C-term region of CIDEA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
Cellular Location Lipid droplet. Nucleus. Note=Enriched at lipid droplet contact sites. Has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062) {ECO:0000250, ECO:0000269|PubMed:18509062}
Tissue Location Expressed in omental and subcutaneous adipose tissue (at protein level).
Research Areas
Citations (0)

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This gene encodes the homolog of the mouse protein Cideathat has been shown to activate apoptosis. This activation ofapoptosis is inhibited by the DNA fragmentation factor DFF45 butnot by caspase inhibitors. Mice that lack functional Cidea havehigher metabolic rates, higher lipolysis in brown adipose tissueand higher core body temperatures when subjected to cold. Thesemice are also resistant to diet-induced obesity and diabetes. Thissuggests that in mice this gene product plays a role inthermogenesis and lipolysis. Alternatively spliced transcripts havebeen identified.


Li, F., et al. FEBS J. 277(20):4173-4183(2010)Ito, M., et al. J. Lipid Res. 51(7):1676-1684(2010)Huang, Y.W., et al. Gynecol. Oncol. 117(2):239-247(2010)Laurencikiene, J., et al. Cancer Res. 68(22):9247-9254(2008)Valouskova, E., et al. Gen. Physiol. Biophys. 27(2):92-100(2008)

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$ 80.00
Cat# BP14057b
(40 western blots)
Availability: In Stock
Bulk Size
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