|Other Names||P2X purinoceptor 5, P2X5, ATP receptor, Purinergic receptor, P2RX5, P2X5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14059b was selected from the C-term region of P2RX5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ATP that acts as a ligand-gated ion channel.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed at high levels in brain and immune system|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family ofpurinoceptors for ATP. This receptor functions as a ligand-gatedion channel. Several characteristic motifs of ATP-gated channelsare present in its primary structure, but, unlike other members ofthe purinoceptors family, this receptor has only a singletransmembrane domain. Three transcript variants encoding distinctisoforms have been identified for this gene.
Kotnis, S., et al. Mol. Pharmacol. 77(6):953-960(2010)Overes, I.M., et al. Cancer Immunol. Immunother. 58(3):429-439(2009)Dubyak, G.R. Mol. Pharmacol. 72(6):1402-1405(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Duckwitz, W., et al. J. Biol. Chem. 281(51):39561-39572(2006)
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