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P2RX5 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q93086 |
|---|---|
| Clone Names | 100507049 |
| Gene ID | 5026 |
|---|---|
| Other Names | P2X purinoceptor 5, P2X5, ATP receptor, Purinergic receptor, P2RX5, P2X5 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14059b was selected from the C-term region of P2RX5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | P2RX5 |
|---|---|
| Synonyms | P2X5 |
| Function | Receptor for ATP that acts as a ligand-gated ion channel. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed at high levels in brain and immune system |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene belongs to the family ofpurinoceptors for ATP. This receptor functions as a ligand-gatedion channel. Several characteristic motifs of ATP-gated channelsare present in its primary structure, but, unlike other members ofthe purinoceptors family, this receptor has only a singletransmembrane domain. Three transcript variants encoding distinctisoforms have been identified for this gene.
References
Kotnis, S., et al. Mol. Pharmacol. 77(6):953-960(2010)Overes, I.M., et al. Cancer Immunol. Immunother. 58(3):429-439(2009)Dubyak, G.R. Mol. Pharmacol. 72(6):1402-1405(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Duckwitz, W., et al. J. Biol. Chem. 281(51):39561-39572(2006)
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