|Other Names||TIR domain-containing adapter molecule 2, TICAM-2, Putative NF-kappa-B-activating protein 502, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein, MyD88-4, TICAM2, TIRAP3, TIRP, TRAM|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14060a was selected from the N-term region of TICAM2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||TIRAP3, TIRP, TRAM|
|Function||Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.|
|Cellular Location||Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes|
|Tissue Location||Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1)|
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Provided below are standard protocols that you may find useful for product applications.
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810)(TIR) domain-containing adaptor protein involved in Toll receptorsignaling (see TLR4; MIM 603030).
Lysakova-Devine, T., et al. J. Immunol. 185(7):4261-4271(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Palsson-McDermott, E.M., et al. Nat. Immunol. 10(6):579-586(2009)Hawn, T.R., et al. PLoS ONE 4 (6), E5990 (2009) :Nakajima, T., et al. Immunogenetics 60(12):727-735(2008)
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