|Other Names||Vesicle-trafficking protein SEC22b, ER-Golgi SNARE of 24 kDa, ERS-24, ERS24, SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1, SEC22B, SEC22L1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14062c was selected from the Center region of SEC22B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type IV membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Melanosome Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the SEC22family of vesicle trafficking proteins. It seems to complex withSNARE and it is thought to play a role in the ER-Golgi proteintrafficking. This protein has strong similarity to Mus musculus andCricetulus griseus proteins.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Chi, A., et al. J. Proteome Res. 5(11):3135-3144(2006)Okumura, A.J., et al. J. Biol. Chem. 281(7):4495-4506(2006)Breuza, L., et al. J. Biol. Chem. 279(45):47242-47253(2004)Nakajima, K., et al. EMBO J. 23(16):3216-3226(2004)
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