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UBP1 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NZI7
Clone Names 100507068
Additional Information
Gene ID 7342
Other Names Upstream-binding protein 1, Transcription factor LBP-1, UBP1, LBP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14065c was selected from the Center region of UBP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBP1
Synonyms LBP1
Function Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA- box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
Cellular Location Nucleus.
Tissue Location Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep- G2 and HeLa cell lines.
Research Areas
Citations (0)
citation

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Background

UBP1 functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.

References

Katsura, A., et al. Genes Cells 14(10):1183-1196(2009)Koutnikova, H., et al. PLoS Genet. 5 (8), E1000591 (2009) :Henderson, Y.C., et al. DNA Cell Biol. 27(2):71-79(2008)Huang, N., et al. Mol. Endocrinol. 19(2):409-420(2005)Huang, N., et al. J. Biol. Chem. 275(4):2852-2858(2000)

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$ 277.78
Cat# BP14065c
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Availability: 2 weeks
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