UBP1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NZI7 |
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Clone Names | 100507068 |
Gene ID | 7342 |
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Other Names | Upstream-binding protein 1, Transcription factor LBP-1, UBP1, LBP1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14065c was selected from the Center region of UBP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | UBP1 |
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Synonyms | LBP1 |
Function | Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA- box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. |
Cellular Location | Nucleus. |
Tissue Location | Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep- G2 and HeLa cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
UBP1 functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
References
Katsura, A., et al. Genes Cells 14(10):1183-1196(2009)Koutnikova, H., et al. PLoS Genet. 5 (8), E1000591 (2009) :Henderson, Y.C., et al. DNA Cell Biol. 27(2):71-79(2008)Huang, N., et al. Mol. Endocrinol. 19(2):409-420(2005)Huang, N., et al. J. Biol. Chem. 275(4):2852-2858(2000)
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