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GLRB Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P48167
Clone Names 110111041
Additional Information
Gene ID 2743
Other Names Glycine receptor subunit beta, Glycine receptor 58 kDa subunit, GLRB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14080c was selected from the Center region of GLRB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLRB
Function Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346, PubMed:34473954). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).
Cellular Location Postsynaptic cell membrane {ECO:0000250|UniProtKB:P48168}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Synapse {ECO:0000250|UniProtKB:P48168} Cell projection, dendrite {ECO:0000250|UniProtKB:P48168}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cytoplasm Note=Retained in the cytoplasm upon heterologous expression by itself Coexpression with GPHN promotes expression at the cell membrane (PubMed:12684523). Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. {ECO:0000250|UniProtKB:P20781, ECO:0000269|PubMed:12684523}
Research Areas
Citations (0)
citation

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Background

This gene encodes the beta subunit of the glycinereceptor, which is a pentamer composed of alpha and beta subunits.The receptor functions as a neurotransmitter-gated ion channel,which produces hyperpolarization via increased chloride conductancedue to the binding of glycine to the receptor. Mutations in thisgene cause startle disease, also known as hereditary hyperekplexiaor congenital stiff-person syndrome, a disease characterized bymuscular rigidity. Alternative splicing results in multipletranscript variants.

References

Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Ziegler, E., et al. Naunyn Schmiedebergs Arch. Pharmacol. 380(4):277-291(2009)Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :Ahrens, J., et al. Pharmacology 83(4):217-222(2009)

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$ 277.78
Cat# BP14080c
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Availability: 2 weeks
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