|Other Names||cAMP-dependent protein kinase catalytic subunit PRKX, PrKX, Protein kinase X, Protein kinase X-linked, Serine/threonine-protein kinase PRKX, PKA-related protein kinase, Prkx, Pkare|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14084a was selected from the N-term region of Mouse Prkx. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.|
|Cellular Location||Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation|
|Tissue Location||Widely expressed.|
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Protein Kinase PKX1 belongs to the AGC Ser/Thr protein kinase family, cAMP subfamily. It contains one AGC-kinase C-terminal domain and one protein kinase domain. It is expressed at high levels in adult and fetal brain, kidney and lung and at low levels in adult placenta, heart, liver, skeletal muscle, pancreas and fetal liver.
Li, X., et al. Biochim. Biophys. Acta 1782(1):1-9(2008)Li, W., et al. J. Histochem. Cytochem. 53(8):1003-1009(2005)Blaschke, R.J., et al. Genomics 64(2):187-194(2000)Blaschke, R.J., et al. Genome Res. 7(12):1114-1117(1997)
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