|Other Names||Calretinin, CR, 29 kDa calbindin, CALB2, CAB29|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14086b was selected from the C-term region of CALB2/CR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calretinin is a calcium-binding protein which is abundant in auditory neurons.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an intracellular calcium-binding proteinbelonging to the troponin C superfamily. Members of this proteinfamily have six EF-hand domains which bind calcium. This proteinplays a role in diverse cellular functions, including messagetargeting and intracellular calcium buffering. It also functions asa modulator of neuronal excitability, and is a diagnostic markerfor some human diseases, including Hirschsprung disease and somecancers. Alternative splicing results in multiple transcriptvariants.
Toth, K., et al. Brain 133(9):2763-2777(2010)Iio, K., et al. Biochem. Biophys. Res. Commun. 393(4):565-570(2010)Raiko, I., et al. BMC Cancer 10, 242 (2010) :Melotti, A., et al. BMC Cancer 10, 54 (2010) :Schwaller, B., et al. Eur. J. Biochem. 230(2):424-430(1995)
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