Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
NMNAT3 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96T66 |
|---|---|
| Clone Names | 101008285 |
| Gene ID | 349565 |
|---|---|
| Other Names | Nicotinamide mononucleotide adenylyltransferase 3, NMN adenylyltransferase 3, Nicotinate-nucleotide adenylyltransferase 3, NaMN adenylyltransferase 3, Pyridine nucleotide adenylyltransferase 3, PNAT-3, NMNAT3 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14087c was selected from the Center region of NMNAT3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NMNAT3 (HGNC:20989) |
|---|---|
| Function | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. |
| Cellular Location | Mitochondrion |
| Tissue Location | Expressed in lung and spleen with lower levels in placenta and kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The coenzyme NAD and its derivatives are involved inhundreds of metabolic redox reactions and are utilized in proteinADP-ribosylation, histone deacetylation, and in some Ca(2+)signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NADbiosynthesis, catalyzing the condensation of nicotinamidemononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) withthe AMP moiety of ATP to form NAD or NaAD (Zhang et al., 2003[PubMed 12574164]).
References
Di Stefano, M., et al. Blood Cells Mol. Dis. 45(1):33-39(2010)Lau, C., et al. J. Biol. Chem. 285(24):18868-18876(2010)Sorci, L., et al. Biochemistry 46(16):4912-4922(2007)Berger, F., et al. J. Biol. Chem. 280(43):36334-36341(2005)Magni, G., et al. Cell. Mol. Life Sci. 61(1):19-34(2004)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
