PCIA1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BW61 |
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Clone Names | 80917122 |
Gene ID | 79016 |
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Other Names | DET1- and DDB1-associated protein 1, Placenta cross-immune reaction antigen 1, PCIA-1, DDA1, C19orf58, PCIA1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14094c was selected from the Center region of PCIA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DDA1 {ECO:0000303|PubMed:17452440, ECO:0000312|HGNC:HGNC:28360} |
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Function | Functions as a component of numerous distinct DCX (DDB1-CUL4- X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28437394, PubMed:28302793, PubMed:31686031, PubMed:31819272). In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex (PubMed:31686031, PubMed:31819272). |
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Provided below are standard protocols that you may find useful for product applications.
Background
PCIA1 may be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.
References
Olma, M.H., et al. J. Cell. Sci. 122 (PT 7), 1035-1044 (2009) :Pick, E., et al. Mol. Cell. Biol. 27(13):4708-4719(2007)Li, Z.M., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24(3):279-283(2007)
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