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SLC38A5 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8WUX1 |
|---|---|
| Clone Names | 100416156 |
| Gene ID | 92745 |
|---|---|
| Other Names | Sodium-coupled neutral amino acid transporter 5, Solute carrier family 38 member 5, System N transporter 2, SLC38A5, JM24, SN2, SNAT5 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14098a was selected from the N-term region of SLC38A5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC38A5 |
|---|---|
| Synonyms | JM24, SN2 {ECO:0000303|PubMed:11243884}, |
| Function | Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11243884). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate- glutamine cycle (By similarity). The transport activity is pH sensitive and Li(+) tolerant (PubMed:11243884). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:A2VCW5}; Multi-pass membrane protein. Note=Localized at astroglial membrane. {ECO:0000250|UniProtKB:A2VCW5} |
| Tissue Location | Predominantly expressed in stomach, brain, liver, lung and intestinal tract. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a system Nsodium-coupled amino acid transporter involved in the transfer ofglutamine, asparagine, histidine, serine, alanine, and glycine. Theencoded protein does not transport charged amino acids, iminoacids, or N-alkylated amino acids. This transporter is notinhibited by lithium.
References
Broer, S. Physiol. Rev. 88(1):249-286(2008)Froyen, G., et al. Hum. Genet. 121(5):539-547(2007)Nakanishi, T., et al. Biochem. Biophys. Res. Commun. 281(5):1343-1348(2001)
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