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IGF1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P05019
Clone Names 100427149
Additional Information
Gene ID 3479
Other Names Insulin-like growth factor I, IGF-I, Mechano growth factor, MGF, Somatomedin-C, IGF1, IBP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14099b was selected from the C-term region of IGF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGF1
Synonyms IBP1
Function The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309).
Cellular Location Secreted {ECO:0000250|UniProtKB:P05017}.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is similar to insulin infunction and structure and is a member of a family of proteinsinvolved in mediating growth and development. The encoded proteinis processed from a precursor, bound by a specific receptor, andsecreted. Defects in this gene are a cause of insulin-like growthfactor I deficiency. Several transcript variants encoding differentisoforms have been found for this gene.

References

Li, M., et al. J. Biol. Chem. 285(40):30480-30488(2010)Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Szczesny, G., et al. Arch Orthop Trauma Surg (2010) In press :

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$ 277.78
Cat# BP14099b
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