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NCK2 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O43639
Clone Names 100430128
Peptide ID 100430128
Additional Information
Gene ID 8440
Other Names Cytoplasmic protein NCK2, Growth factor receptor-bound protein 4, NCK adaptor protein 2, Nck-2, SH2/SH3 adaptor protein NCK-beta, NCK2, GRB4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14107a was selected from the N-term region of NCK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCK2
Synonyms GRB4
Function Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling.
Cellular Location Cytoplasm. Endoplasmic reticulum
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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This gene encodes a member of the NCK family of adaptorproteins. The protein contains three SH3 domains and one SH2domain. The protein has no known catalytic function but has beenshown to bind and recruit various proteins involved in theregulation of receptor protein tyrosine kinases. It is throughthese regulatory activities that this protein is believed to beinvolved in cytoskeletal reorganization. Alternate transcriptionalsplice variants, encoding different isoforms, have beencharacterized.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Guan, S., et al. J. Invest. Dermatol. 129(8):1909-1920(2009)Liu, J., et al. PLoS ONE 4 (11), E7805 (2009) :Akiyama, M., et al. Br J Ophthalmol 92(9):1293-1296(2008)Park, S., et al. J. Biomol. NMR 34(3):203-208(2006)

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$ 80.00
Cat# BP14107a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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