|Other Names||Transcription initiation factor IIE subunit beta, TFIIE-beta, General transcription factor IIE subunit 2, GTF2E2, TF2E2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14111b was selected from the C-term region of GTF2E2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|
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Provided below are standard protocols that you may find useful for product applications.
GTF2E2 recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)Tanaka, A., et al. Genes Cells 14(3):395-405(2009)Jawhari, A., et al. EMBO Rep. 7(5):500-505(2006)Watanabe, T., et al. Mol. Cell. Biol. 23(8):2914-2926(2003)
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