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GTF2E2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P29084 |
|---|---|
| Clone Names | 100430304 |
| Gene ID | 2961 |
|---|---|
| Other Names | Transcription initiation factor IIE subunit beta, TFIIE-beta, General transcription factor IIE subunit 2, GTF2E2, TF2E2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14111b was selected from the C-term region of GTF2E2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GTF2E2 |
|---|---|
| Synonyms | TF2E2 |
| Function | Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GTF2E2 recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
References
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)Tanaka, A., et al. Genes Cells 14(3):395-405(2009)Jawhari, A., et al. EMBO Rep. 7(5):500-505(2006)Watanabe, T., et al. Mol. Cell. Biol. 23(8):2914-2926(2003)
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