|Other Names||Bone sialoprotein 2, Bone sialoprotein II, BSP II, Cell-binding sialoprotein, Integrin-binding sialoprotein, IBSP, BNSP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14114a was selected from the N-term region of IBSP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|
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The protein encoded by this gene is a major structuralprotein of the bone matrix. It constitutes approximately 12% of thenoncollagenous proteins in human bone and is synthesized byskeletal-associated cell types, including hypertrophicchondrocytes, osteoblasts, osteocytes, and osteoclasts. The onlyextraskeletal site of its synthesis is the trophoblast. Thisprotein binds to calcium and hydroxyapatite via its acidic aminoacid clusters, and mediates cell attachment through an RGD sequencethat recognizes the vitronectin receptor.
Giroux, S., et al. Bone 47(5):975-981(2010)Koller, D.L., et al. J. Clin. Endocrinol. Metab. 95(4):1802-1809(2010)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Gordon, J.A., et al. J. Cell. Biochem. 107(6):1118-1128(2009)Hwang, Q., et al. BMC Cancer 9, 121 (2009) :
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