|Other Names||Amino-terminal enhancer of split, Amino enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, AES, GRG, GRG5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14115b was selected from the C-term region of AES. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.|
|Tissue Location||Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver|
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The protein encoded by this gene is similar in sequence tothe amino terminus of Drosophila enhancer of split groucho, aprotein involved in neurogenesis during embryonic development. Theencoded protein, which belongs to the groucho/TLE family ofproteins, can function as a homooligomer or as a heteroologimerwith other family members to dominantly repress the expression ofother family member genes. Three transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Zhang, Y., et al. Biochem. J. 427(3):499-511(2010)Beagle, B., et al. PLoS ONE 5 (7), E11821 (2010) :Arce, L., et al. BMC Cancer 9, 159 (2009) :Zhang, X., et al. J. Neurosci. Res. 86(11):2423-2431(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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