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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CFL2 Antibody (N-term) Blocking peptide   

CFL2 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9Y281
Clone Names 100507017
Peptide ID 100507017
Additional Information
Gene ID 1073
Other Names Cofilin-2, Cofilin, muscle isoform, CFL2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14117a was selected from the N-term region of CFL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFL2
Function Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
Cellular Location Nucleus matrix. Cytoplasm, cytoskeleton
Tissue Location Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues
Research Areas
Citations (0)

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This gene encodes an intracellular protein that isinvolved in the regulation of actin-filament dynamics. This proteinis a major component of intranuclear and cytoplasmic actin rods. Itcan bind G- and F-actin in a 1:1 ratio of cofilin to actin, and itreversibly controls actin polymerization and depolymerization in apH-dependent manner. Mutations in this gene cause nemaline myopathytype 7, a form of congenital myopathy. Alternative splicing resultsin multiple transcript variants.


Vogel, S., et al. J. Biol. Chem. 285(44):33756-33763(2010)Borensztajn, K., et al. Thromb. Res. 125 (6), E323-E328 (2010) :Papalouka, V., et al. Mol. Cell. Biol. 29(22):6046-6058(2009)Wu, Y., et al. Retrovirology 5, 95 (2008) :Agrawal, P.B., et al. Am. J. Hum. Genet. 80(1):162-167(2007)

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$ 80.00
Cat# BP14117a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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