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SOCS6 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O14544
Clone Names 100507057
Peptide ID 100507057
Additional Information
Gene ID 9306
Other Names Suppressor of cytokine signaling 6, SOCS-6, Cytokine-inducible SH2 protein 4, CIS-4, Suppressor of cytokine signaling 4, SOCS-4, SOCS6, CIS4, SOCS4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14118a was selected from the N-term region of SOCS6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOCS6
Synonyms CIS4, SOCS4
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Research Areas
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The protein encoded by this gene contains a SH2 domain anda CIS homolog domain. The protein thus belongs to thecytokine-induced STAT inhibitor (CIS), also known as suppressor ofcytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI),protein family. CIS family members are known to becytokine-inducible negative regulators of cytokine signaling. Theexpression of this gene can be induced by GM-CSF and EPO inhematopoietic cells. A high expression level of this gene was foundin factor-independent chronic myelogenous leukemia (CML) anderythroleukemia (HEL) cell lines.


Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Choi, Y.B., et al. J. Biol. Chem. 285(10):7271-7280(2010)Lai, R.H., et al. Gene 448(1):64-73(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 80.00
Cat# BP14118a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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