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SOCS6 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O14544 |
|---|---|
| Clone Names | 100507057 |
| Gene ID | 9306 |
|---|---|
| Other Names | Suppressor of cytokine signaling 6, SOCS-6, Cytokine-inducible SH2 protein 4, CIS-4, Suppressor of cytokine signaling 4, SOCS-4, SOCS6, CIS4, SOCS4 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14118a was selected from the N-term region of SOCS6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SOCS6 |
|---|---|
| Synonyms | CIS4, SOCS4 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains a SH2 domain anda CIS homolog domain. The protein thus belongs to thecytokine-induced STAT inhibitor (CIS), also known as suppressor ofcytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI),protein family. CIS family members are known to becytokine-inducible negative regulators of cytokine signaling. Theexpression of this gene can be induced by GM-CSF and EPO inhematopoietic cells. A high expression level of this gene was foundin factor-independent chronic myelogenous leukemia (CML) anderythroleukemia (HEL) cell lines.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Choi, Y.B., et al. J. Biol. Chem. 285(10):7271-7280(2010)Lai, R.H., et al. Gene 448(1):64-73(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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