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RBM39 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14498 |
|---|---|
| Clone Names | 100507060 |
| Gene ID | 9584 |
|---|---|
| Other Names | RNA-binding protein 39, CAPER alpha, Hepatocellular carcinoma protein 1, RNA-binding motif protein 39, RNA-binding region-containing protein 2, Splicing factor HCC1, RBM39, HCC1, RNPC2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14119a was selected from the N-term region of RBM39. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RBM39 {ECO:0000303|PubMed:28302793, ECO:0000312|HGNC:HGNC:15923} |
|---|---|
| Function | RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:31271494, PubMed:28437394, PubMed:28302793, PubMed:24795046). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). |
| Cellular Location | Nucleus speckle. Note=Concentrated in nuclear speckles (PubMed:8227358). Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358) |
| Tissue Location | Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain (PubMed:8227358). Expressed at intermediate level in kidney, liver and heart (PubMed:8227358) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an RNA binding proteinand possible splicing factor. The encoded protein is found in thenucleus, where it colocalizes with core spliceosomal proteins.Studies of a mouse protein with high sequence similarity to thisprotein suggest that this protein may act as a transcriptionalcoactivator for JUN/AP-1 and estrogen receptors. Multipletranscript variants encoding different isoforms have been observedfor this gene.
References
Mercier, I., et al. Am. J. Pathol. 174(4):1172-1190(2009)Dutta, J., et al. J. Virol. 82(21):10792-10802(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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