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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   APLNR Antibody (Center) Blocking peptide   

APLNR Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P35414
Clone Names 100507319
Peptide ID 100507319
Additional Information
Gene ID 187
Other Names Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11, APLNR, AGTRL1, APJ
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14123c was selected from the Center region of APLNR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms AGTRL1, APJ
Function Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon
Research Areas
Citations (0)

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This gene encodes a member of the G protein-coupledreceptor gene family. The encoded protein is related to theangiotensin receptor, but is actually an apelin receptor thatinhibits adenylate cyclase activity and plays a counter-regulatoryrole against the pressure action of angiotensin II by exertinghypertensive effect. It functions in the cardiovascular and centralnervous systems, in glucose metabolism, in embryonic and tumorangiogenesis and as a human immunodeficiency virus (HIV-1)coreceptor. Two transcript variants resulting from alternativesplicing have been identified.


Tao, Y., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4237-4242(2010)Zhao, Q., et al. Am. J. Hypertens. 23(6):606-613(2010)Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395(2):185-189(2010)Falcao-Pires, I., et al. Expert Opin. Ther. Targets 14(3):231-241(2010)Peltonen, T., et al. J. Heart Valve Dis. 18(6):644-652(2009)

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$ 80.00
Cat# BP14123c
Availability: In Stock
Bulk Size
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