|Other Names||Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11, APLNR, AGTRL1, APJ|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14123c was selected from the Center region of APLNR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon|
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This gene encodes a member of the G protein-coupledreceptor gene family. The encoded protein is related to theangiotensin receptor, but is actually an apelin receptor thatinhibits adenylate cyclase activity and plays a counter-regulatoryrole against the pressure action of angiotensin II by exertinghypertensive effect. It functions in the cardiovascular and centralnervous systems, in glucose metabolism, in embryonic and tumorangiogenesis and as a human immunodeficiency virus (HIV-1)coreceptor. Two transcript variants resulting from alternativesplicing have been identified.
Tao, Y., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4237-4242(2010)Zhao, Q., et al. Am. J. Hypertens. 23(6):606-613(2010)Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395(2):185-189(2010)Falcao-Pires, I., et al. Expert Opin. Ther. Targets 14(3):231-241(2010)Peltonen, T., et al. J. Heart Valve Dis. 18(6):644-652(2009)
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