|Other Names||Aldo-keto reductase family 1 member B10, 111-, ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase, AKR1B10, AKR1B11|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14125c was selected from the Center region of AKR1B10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.|
|Cellular Location||Lysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway|
|Tissue Location||Found in many tissues. Highly expressed in small intestine, colon and adrenal gland|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the aldo/keto reductasesuperfamily, which consists of more than 40 known enzymes andproteins. This member can efficiently reduce aliphatic and aromaticaldehydes, and it is less active on hexoses. It is highly expressedin adrenal gland, small intestine, and colon, and may play animportant role in liver carcinogenesis.
Bailey, S.D., et al. Diabetes Care (2010) In press :Kropotova, E.S., et al. Mol. Biol. (Mosk.) 44(2):243-250(2010)Heringlake, S., et al. J. Hepatol. 52(2):220-227(2010)Ravindranath, T.M., et al. J. Immunol. 183(12):8128-8137(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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