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AKR1B10 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O60218
Clone Names 100517004
Additional Information
Gene ID 57016
Other Names Aldo-keto reductase family 1 member B10, 111-, ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase, AKR1B10, AKR1B11
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14125c was selected from the Center region of AKR1B10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKR1B10
Synonyms AKR1B11
Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans- retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4- hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097).
Cellular Location Lysosome. Secreted. Note=Secreted through a lysosome- mediated non-classical pathway
Tissue Location Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the aldo/keto reductasesuperfamily, which consists of more than 40 known enzymes andproteins. This member can efficiently reduce aliphatic and aromaticaldehydes, and it is less active on hexoses. It is highly expressedin adrenal gland, small intestine, and colon, and may play animportant role in liver carcinogenesis.

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Kropotova, E.S., et al. Mol. Biol. (Mosk.) 44(2):243-250(2010)Heringlake, S., et al. J. Hepatol. 52(2):220-227(2010)Ravindranath, T.M., et al. J. Immunol. 183(12):8128-8137(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 277.78
Cat# BP14125c
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Availability: 2 weeks
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