AKR1B10 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O60218 |
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Clone Names | 100517004 |
Gene ID | 57016 |
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Other Names | Aldo-keto reductase family 1 member B10, 111-, ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase, AKR1B10, AKR1B11 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14125c was selected from the Center region of AKR1B10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AKR1B10 |
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Synonyms | AKR1B11 |
Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans- retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4- hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). |
Cellular Location | Lysosome. Secreted. Note=Secreted through a lysosome- mediated non-classical pathway |
Tissue Location | Found in many tissues. Highly expressed in small intestine, colon and adrenal gland. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the aldo/keto reductasesuperfamily, which consists of more than 40 known enzymes andproteins. This member can efficiently reduce aliphatic and aromaticaldehydes, and it is less active on hexoses. It is highly expressedin adrenal gland, small intestine, and colon, and may play animportant role in liver carcinogenesis.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Kropotova, E.S., et al. Mol. Biol. (Mosk.) 44(2):243-250(2010)Heringlake, S., et al. J. Hepatol. 52(2):220-227(2010)Ravindranath, T.M., et al. J. Immunol. 183(12):8128-8137(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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