|Other Names||Far upstream element-binding protein 1, FBP, FUSE-binding protein 1, DNA helicase V, hDH V, FUBP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14126c was selected from the Center region of FUBP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a ssDNA binding protein that activatesthe far upstream element (FUSE) of c-myc and stimulates expressionof c-myc in undifferentiated cells. Regulation of FUSE by FUBPoccurs through single-strand binding of FUBP to the non-codingstrand. This protein has been shown to function as an ATP-dependentDNA helicase.
Hsiao, H.H., et al. Biochemistry 49(22):4620-4634(2010)Rabenhorst, U., et al. Hepatology 50(4):1121-1129(2009)Malz, M., et al. Hepatology 50(4):1130-1139(2009)Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Jang, M., et al. Oncogene 28(12):1529-1536(2009)
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