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RPH3A Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y2J0 |
|---|---|
| Clone Names | 100517034 |
| Gene ID | 22895 |
|---|---|
| Other Names | Rabphilin-3A, Exophilin-1, RPH3A, KIAA0985 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14129b was selected from the C-term region of RPH3A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RPH3A |
|---|---|
| Synonyms | KIAA0985 |
| Function | Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP- dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P47709}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P47709}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P47709}. Membrane {ECO:0000250|UniProtKB:P47709}; Peripheral membrane protein {ECO:0000250|UniProtKB:P47709} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Exocytosis of neurotransmitters and hormones isfundamental to synaptic neurotransmission and cell-cellcommunication. RAB3A (MIM 179390) is a small G protein that isthought to act at late stages of exocytosis, and RPH3A is a RAB3Aeffector (Lin et al., 2007 [PubMed 17149709]).
References
Katkoori, V.R., et al. Front. Biosci. 13, 1050-1061 (2008) :Smith, R., et al. J. Neurochem. 103(1):115-123(2007)Lin, C.C., et al. J. Cell. Physiol. 211(2):316-326(2007)Dalfo, E., et al. Neurobiol. Dis. 16(1):92-97(2004)Rastaldi, M.P., et al. Am. J. Pathol. 163(3):889-899(2003)
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