|Other Names||Rabphilin-3A, Exophilin-1, RPH3A, KIAA0985|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14129b was selected from the C-term region of RPH3A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity).|
|Cellular Location||Cell junction, synapse. Membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Exocytosis of neurotransmitters and hormones isfundamental to synaptic neurotransmission and cell-cellcommunication. RAB3A (MIM 179390) is a small G protein that isthought to act at late stages of exocytosis, and RPH3A is a RAB3Aeffector (Lin et al., 2007 [PubMed 17149709]).
Katkoori, V.R., et al. Front. Biosci. 13, 1050-1061 (2008) :Smith, R., et al. J. Neurochem. 103(1):115-123(2007)Lin, C.C., et al. J. Cell. Physiol. 211(2):316-326(2007)Dalfo, E., et al. Neurobiol. Dis. 16(1):92-97(2004)Rastaldi, M.P., et al. Am. J. Pathol. 163(3):889-899(2003)
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