|Other Names||Proto-oncogene Wnt-3, Proto-oncogene Int-4 homolog, WNT3, INT4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14130c was selected from the Center region of WNT3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406).|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
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Provided below are standard protocols that you may find useful for product applications.
The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Itencodes a protein which shows 98% amino acid identity to mouse Wnt3protein, and 84% to human WNT3A protein, another WNT gene product.The mouse studies show the requirement of Wnt3 in primary axisformation in the mouse. Studies of the gene expression suggest thatthis gene may play a key role in some cases of human breast,rectal, lung, and gastric cancer through activation of theWNT-beta-catenin-TCF signaling pathway. This gene is clustered withWNT15, another family member, in the chromosome 17q21 region.
Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Memarian, A., et al. Leuk. Lymphoma 50(12):2061-2070(2009)
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