|Other Names||Trace amine-associated receptor 6, TaR-6, Trace amine receptor 6, Trace amine receptor 4, TaR-4, TAAR6, TA4, TAR4, TRAR4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14131b was selected from the C-term region of TAAR6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||TA4, TAR4, TRAR4|
|Function||Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta. In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia.|
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This gene encodes a seven-transmembrane G-protein-coupledreceptor that likely functions as a receptor for endogenous traceamines. Mutations in this gene may be associated withschizophrenia.
Pae, C.U., et al. Psychiatry Res 180(1):20-24(2010)Pae, C.U., et al. Neurosci. Lett. 465(3):257-261(2009)Pae, C.U., et al. Eur Neuropsychopharmacol 19(11):806-811(2009)Serretti, A., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 33(5):822-826(2009)Duan, S., et al. J Neural Transm 113(3):381-385(2006)
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