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MAPKAP1 Antibody (C-term) Blocking PeptidesSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP14132b | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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MAPKAP1 Antibody (C-term) Blocking Peptides - Product info | |
| Primary Accession | Q9BPZ7 |
| Clone Names | 100517073 |
| Calculated MW | 59123 Da |
MAPKAP1 Antibody (C-term) Blocking Peptides - Additional info | |
| Gene ID 79109 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP14132b was selected from the C-term region of MAPKAP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
MAPKAP1 Antibody (C-term) Blocking Peptides - Protein Information | |
| Name MAPKAP1 | |
| Synonyms MIP1, SIN1 | |
| Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription | |
| Cellular Location Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus | |
| Tissue Location Ubiquitously expressed, with highest levels in heart and skeletal muscle | |
MAPKAP1 Antibody (C-term) Blocking Peptides - Related products
MAPKAP1 Antibody (C-term) Blocking Peptides - Research Areas
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BACKGROUND
This gene encodes a protein that is highly similar to theyeast SIN1 protein, a stress-activated protein kinase.Alternatively spliced transcript variants encoding distinctisoforms have been described. Alternate polyadenylation sites aswell as alternate 3' UTRs have been identified for transcripts ofthis gene.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
