|Other Names||Mitogen-activated protein kinase kinase kinase 9, Map3k9|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14135b was selected from the C-term region of Mouse Map3k9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis (By similarity).|
|Tissue Location||Expressed in cochlea and utricle.|
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Provided below are standard protocols that you may find useful for product applications.
Map3k9 activates the JUN N-terminal pathway.
Craig, E.A., et al. Dev. Dyn. 237(11):3102-3114(2008)Bisson, N., et al. Cell Cycle 7(7):909-916(2008)Kihara, T., et al. Exp. Cell Res. 314(3):629-637(2008)Piao, Y., et al. Genome Res. 11(9):1553-1558(2001)
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