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Mouse Map3k9 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q3U1V8 |
|---|---|
| Clone Names | 110316237 |
| Gene ID | 338372 |
|---|---|
| Other Names | Mitogen-activated protein kinase kinase kinase 9, Map3k9 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14135b was selected from the C-term region of Mouse Map3k9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Map3k9 |
|---|---|
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis (By similarity). |
| Tissue Location | Expressed in cochlea and utricle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Map3k9 activates the JUN N-terminal pathway.
References
Craig, E.A., et al. Dev. Dyn. 237(11):3102-3114(2008)Bisson, N., et al. Cell Cycle 7(7):909-916(2008)Kihara, T., et al. Exp. Cell Res. 314(3):629-637(2008)Piao, Y., et al. Genome Res. 11(9):1553-1558(2001)
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