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Mouse Mapk6 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q61532 |
|---|---|
| Clone Names | 110316252 |
| Gene ID | 50772 |
|---|---|
| Other Names | Mitogen-activated protein kinase 6, MAP kinase 6, MAPK 6, Extracellular signal-regulated kinase 3, ERK-3, Mapk6, Erk3, Prkm4, Prkm6 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14136c was selected from the Center region of Mouse Mapk6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Mapk6 |
|---|---|
| Synonyms | Erk3, Prkm4, Prkm6 |
| Function | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle. |
| Cellular Location | Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5 |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Mapk6 phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity).
References
Klinger, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(39):16710-16715(2009)Bae, G.U., et al. Mol. Cell. Biol. 29(15):4130-4143(2009)Sabio, G., et al. EMBO J. 24(6):1134-1145(2005)Seternes, O.M., et al. EMBO J. 23(24):4780-4791(2004)Schumacher, S., et al. EMBO J. 23(24):4770-4779(2004)
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