|Other Names||Mitogen-activated protein kinase 6, MAP kinase 6, MAPK 6, Extracellular signal-regulated kinase 3, ERK-3, Mapk6, Erk3, Prkm4, Prkm6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14136c was selected from the Center region of Mouse Mapk6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||Erk3, Prkm4, Prkm6|
|Function||Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5|
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Provided below are standard protocols that you may find useful for product applications.
Mapk6 phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity).
Klinger, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(39):16710-16715(2009)Bae, G.U., et al. Mol. Cell. Biol. 29(15):4130-4143(2009)Sabio, G., et al. EMBO J. 24(6):1134-1145(2005)Seternes, O.M., et al. EMBO J. 23(24):4780-4791(2004)Schumacher, S., et al. EMBO J. 23(24):4770-4779(2004)
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