|Other Names||Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, MTS-2, p14-INK4b, p15-INK4b, p15INK4B, CDKN2B, MTS2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14138b was selected from the C-term region of CDKN2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.|
|Cellular Location||Cytoplasm. Note=Also found in the nucleus|
|Tissue Location||Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines|
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This gene lies adjacent to the tumor suppressor geneCDKN2A in a region that is frequently mutated and deleted in a widevariety of tumors. This gene encodes a cyclin-dependent kinaseinhibitor, which forms a complex with CDK4 or CDK6, and preventsthe activation of the CDK kinases, thus the encoded proteinfunctions as a cell growth regulator that controls cell cycle G1progression. The expression of this gene was found to bedramatically induced by TGF beta, which suggested its role in theTGF beta induced growth inhibition. Two alternatively splicedtranscript variants of this gene, which encode distinct proteins,have been reported.
Camacho, C.V., et al. Carcinogenesis 31(10):1889-1896(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1867-1872(2010)Heni, M., et al. Diabetes (2010) In press :Roder, C., et al. Childs Nerv Syst (2010) In press :
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