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SPN/CD43 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P16150
Clone Names 101229057
Peptide ID 101229057
Additional Information
Gene ID 6693
Other Names Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14144a was selected from the N-term region of SPN/CD43. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPN
Synonyms CD43
Function Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T- cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter- receptor for SIGLEC1 (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein. Cell projection, microvillus {ECO:0000250|UniProtKB:P13838}. Cell projection, uropodium {ECO:0000250|UniProtKB:P15702}. Note=Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). {ECO:0000250|UniProtKB:P13838, ECO:0000250|UniProtKB:P15702}
Tissue Location Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas
Research Areas
Citations (0)

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Background

Sialophorin (leukosialin) is a major sialoglycoprotein onthe surface of human T lymphocytes, monocytes, granulocytes, andsome B lymphocytes, which appears to be important for immunefunction and may be part of a physiologic ligand-receptor complexinvolved in T-cell activation.

References

Urano-Tashiro, Y., et al. Infect. Immun. 76(10):4686-4691(2008)Mambole, A., et al. J. Biol. Chem. 283(35):23627-23635(2008)Seethala, R.R., et al. Appl. Immunohistochem. Mol. Morphol. 16(2):165-172(2008)Khunkaewla, P., et al. Mol. Immunol. 45(6):1703-1711(2008)Rawal, A., et al. Arch. Pathol. Lab. Med. 131(11):1673-1678(2007)

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$ 80.00
Cat# BP14144a
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