|Other Names||Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14144a was selected from the N-term region of SPN/CD43. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas|
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Sialophorin (leukosialin) is a major sialoglycoprotein onthe surface of human T lymphocytes, monocytes, granulocytes, andsome B lymphocytes, which appears to be important for immunefunction and may be part of a physiologic ligand-receptor complexinvolved in T-cell activation.
Urano-Tashiro, Y., et al. Infect. Immun. 76(10):4686-4691(2008)Mambole, A., et al. J. Biol. Chem. 283(35):23627-23635(2008)Seethala, R.R., et al. Appl. Immunohistochem. Mol. Morphol. 16(2):165-172(2008)Khunkaewla, P., et al. Mol. Immunol. 45(6):1703-1711(2008)Rawal, A., et al. Arch. Pathol. Lab. Med. 131(11):1673-1678(2007)
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