|Other Names||Kinase suppressor of Ras 1, mKSR1, Protein Hb, Ksr1, Ksr|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14150b was selected from the C-term region of Mouse Ksr1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Endoplasmic reticulum membrane. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery|
|Tissue Location||Expressed in brain, spleen and testis. Isoform 1 is highly expressed spleen and weakly in testis, and isoform 2 is highly expressed in brain and weakly in testis|
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Provided below are standard protocols that you may find useful for product applications.
Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
Costanzo-Garvey, D.L., et al. Cell Metab. 10(5):366-378(2009)McKay, M.M., et al. Proc. Natl. Acad. Sci. U.S.A. 106(27):11022-11027(2009)Razidlo, G.L., et al. J. Biol. Chem. 284(11):6705-6715(2009)Giurisato, E., et al. Mol. Cell. Biol. 29(6):1554-1564(2009)Casar, B., et al. Mol. Cell. Biol. 29(5):1338-1353(2009)
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