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Mouse Ksr1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q61097
Clone Names 110316204
Peptide ID 110316204
Additional Information
Gene ID 16706
Other Names Kinase suppressor of Ras 1, mKSR1, Protein Hb, Ksr1, Ksr
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14150b was selected from the C-term region of Mouse Ksr1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ksr1
Synonyms Ksr
Function Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases (PubMed:10409742, PubMed:12932319, PubMed:21102438). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (PubMed:21102438). Does not have kinase activity by itself (Probable).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cell projection, ruffle membrane. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8IVT5}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery
Tissue Location Expressed in brain, spleen and testis. Isoform 1 is highly expressed spleen and weakly in testis, and isoform 2 is highly expressed in brain and weakly in testis
Research Areas
Citations (0)

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Background

Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.

References

Costanzo-Garvey, D.L., et al. Cell Metab. 10(5):366-378(2009)McKay, M.M., et al. Proc. Natl. Acad. Sci. U.S.A. 106(27):11022-11027(2009)Razidlo, G.L., et al. J. Biol. Chem. 284(11):6705-6715(2009)Giurisato, E., et al. Mol. Cell. Biol. 29(6):1554-1564(2009)Casar, B., et al. Mol. Cell. Biol. 29(5):1338-1353(2009)

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$ 80.00
Cat# BP14150b
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