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Mouse Ltk Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P08923 |
|---|---|
| Clone Names | 110316213 |
| Gene ID | 17005 |
|---|---|
| Other Names | Leukocyte tyrosine kinase receptor, Ltk |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14152b was selected from the C-term region of Mouse Ltk. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Ltk {ECO:0000303|PubMed:2357970} |
|---|---|
| Function | Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (By similarity). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity). The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein [Isoform B]: Endoplasmic reticulum. Note=Retained in the endoplasmic reticulum. |
| Tissue Location | Subsets of lymphoid and neuronal cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of theros/insulin receptor family of tyrosine kinases. Tyrosine-specificphosphorylation of proteins is a key to the control of diversepathways leading to cell growth and differentiation. Fouralternatively spliced transcript variants encoding differentisoforms have been described for this gene. These transcripts areexpressed in a tissue-specific manner in lymphocytes, brain andneuroblastoma cells, and the encoded isoforms exhibit differentsubcellular localization. The lymphocyte and brain specificvariants initiate translation at non-AUG (CUG) start codons.
References
Li, J., et al. J. Biol. Chem. 283(49):34260-34272(2008)Yu, X., et al. J. Immunol. 177(10):7042-7049(2006)Li, N., et al. Hum. Mol. Genet. 13(2):171-179(2004)Thut, C.J., et al. Dev. Biol. 231(1):63-76(2001)Robinson, D.R., et al. Oncogene 19(49):5548-5557(2000)
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