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Mouse Ltk Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P08923
Clone Names 110316213
Peptide ID 110316213
Additional Information
Gene ID 17005
Other Names Leukocyte tyrosine kinase receptor, Ltk
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14152b was selected from the C-term region of Mouse Ltk. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ltk
Function Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein Isoform B: Endoplasmic reticulum. Note=Retained in the endoplasmic reticulum
Tissue Location Subsets of lymphoid and neuronal cells.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of theros/insulin receptor family of tyrosine kinases. Tyrosine-specificphosphorylation of proteins is a key to the control of diversepathways leading to cell growth and differentiation. Fouralternatively spliced transcript variants encoding differentisoforms have been described for this gene. These transcripts areexpressed in a tissue-specific manner in lymphocytes, brain andneuroblastoma cells, and the encoded isoforms exhibit differentsubcellular localization. The lymphocyte and brain specificvariants initiate translation at non-AUG (CUG) start codons.


Li, J., et al. J. Biol. Chem. 283(49):34260-34272(2008)Yu, X., et al. J. Immunol. 177(10):7042-7049(2006)Li, N., et al. Hum. Mol. Genet. 13(2):171-179(2004)Thut, C.J., et al. Dev. Biol. 231(1):63-76(2001)Robinson, D.R., et al. Oncogene 19(49):5548-5557(2000)

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$ 80.00
Cat# BP14152b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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