|Other Names||Leukocyte tyrosine kinase receptor, Ltk|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14152b was selected from the C-term region of Mouse Ltk. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Isoform B: Endoplasmic reticulum. Note=Retained in the endoplasmic reticulum|
|Tissue Location||Subsets of lymphoid and neuronal cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theros/insulin receptor family of tyrosine kinases. Tyrosine-specificphosphorylation of proteins is a key to the control of diversepathways leading to cell growth and differentiation. Fouralternatively spliced transcript variants encoding differentisoforms have been described for this gene. These transcripts areexpressed in a tissue-specific manner in lymphocytes, brain andneuroblastoma cells, and the encoded isoforms exhibit differentsubcellular localization. The lymphocyte and brain specificvariants initiate translation at non-AUG (CUG) start codons.
Li, J., et al. J. Biol. Chem. 283(49):34260-34272(2008)Yu, X., et al. J. Immunol. 177(10):7042-7049(2006)Li, N., et al. Hum. Mol. Genet. 13(2):171-179(2004)Thut, C.J., et al. Dev. Biol. 231(1):63-76(2001)Robinson, D.R., et al. Oncogene 19(49):5548-5557(2000)
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