|Other Names||Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MAPK/ERK kinase 5, MEK 5, Map2k5, Mek5, Mkk5, Prkmk5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14154b was selected from the C-term region of Mouse Map2k5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||Mek5, Mkk5, Prkmk5|
|Function||Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
Map2k5 acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
Spiering, D., et al. J. Biol. Chem. 284(37):24972-24980(2009)Carter, E.J., et al. J. Cell. Sci. 122 (PT 17), 3104-3112 (2009) :Sohn, S.J., et al. EMBO J. 27(13):1896-1906(2008)Shishido, T., et al. Circ. Res. 102(11):1416-1425(2008)Nakamura, K., et al. Mol. Cell. Biol. 27(12):4566-4577(2007)
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