|Other Names||Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4, Mlk4, Kiaa1804|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14157c was selected from the Center region of Mouse Mlk4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Mlk4 activates the JUN N-terminal pathway (By similarity).
Katayama, S., et al. Science 309(5740):1564-1566(2005)
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