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RC3H1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q5TC82
Clone Names 100617051
Peptide ID 100617051
Additional Information
Gene ID 149041
Other Names Roquin-1, Roquin, RING finger and C3H zinc finger protein 1, RING finger and CCCH-type zinc finger domain-containing protein 1, RING finger protein 198, RC3H1, KIAA2025, RNF198
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14162b was selected from the C-term region of RC3H1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RC3H1
Synonyms KIAA2025, RNF198
Function Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS- stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity).
Cellular Location Cytoplasm, P-body {ECO:0000250|UniProtKB:Q4VGL6}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q4VGL6}. Note=During stress, such as that induced by arsenite treatment, localizes to cytosolic stress granules (By similarity). Localization to stress granules, but not to P-bodies, depends upon the RING-type zinc finger (By similarity). ICOS repression may correlate with the localization to P-bodies, not to stress granules (By similarity) {ECO:0000250|UniProtKB:Q4VGL6}
Tissue Location Widely expressed. Expressed at higher level in cerebellum, spleen, ovary and liver. {ECO:0000269|Ref.3}
Research Areas
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Background

RC3H1, or roquin, encodes a highly conserved member of theRING type ubiquitin ligase protein family (Vinuesa et al., 2005[PubMed 15917799]). The roquin protein is distinguished by thepresence of a CCCH zinc finger found in RNA-binding proteins, andlocalization to cytosolic RNA granules implicated in regulatingmRNA translation and stability.

References

Vinuesa, C.G., et al. Nature 435(7041):452-458(2005)

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$ 80.00
Cat# BP14162b
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