|Other Names||Vascular endothelial growth factor receptor 3, VEGFR-3, Fms-like tyrosine kinase 4, FLT-4, Tyrosine-protein kinase receptor FLT4, Flt4, Flt-4, Vegfr3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14163a was selected from the N-term region of Mouse Flt4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr- 185', and of AKT1 at 'Ser-473'.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Cytoplasm. Nucleus Note=Ligand-mediated autophosphorylation leads to rapid internalization|
|Tissue Location||Expressed in adult lung and liver, and in fetal liver, brain, intestine and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Flt4 is a receptor for VEGFC. Has a tyrosine-protein kinase activity.
Proulx, S.T., et al. Cancer Res. 70(18):7053-7062(2010)Corada, M., et al. Dev. Cell 18(6):938-949(2010)Chen, L., et al. J. Cell Biol. 189(3):417-424(2010)Nakamura, M., et al. J. Gastroenterol. Hepatol. 25 SUPPL 1, S1-S6 (2010) :Kim, H., et al. BMC Dev. Biol. 10, 72 (2010) :
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