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Mouse Ikbkb Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O88351
Clone Names 110316190
Peptide ID 110316190
Additional Information
Gene ID 16150
Other Names Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB, I-kappa-B kinase 2, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, NFKBIKB, Ikbkb, Ikkb
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14164c was selected from the Center region of Mouse Ikbkb. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ikbkb
Synonyms Ikkb
Function Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (By similarity).
Cellular Location Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Tissue Location Expressed in liver, kidney and spleen.
Research Areas
Citations (0)

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Ikbkb acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3 (By similarity).


Busuttil, V., et al. Proc. Natl. Acad. Sci. U.S.A. 107(42):18061-18066(2010)Kenneth, N.S., et al. EMBO J. 29(17):2966-2978(2010)Tsuchiya, Y., et al. Mol. Cell 39(4):570-582(2010)Farlik, M., et al. Immunity 33(1):25-34(2010)Dong, X., et al. PLoS Pathog. 6 (7), E1001001 (2010) :

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$ 80.00
Cat# BP14164c
(40 western blots)
Availability: In Stock
Bulk Size
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