|Other Names||Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1, FOXO3, FKHRL1, FOXO3A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors|
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This gene belongs to the forkhead family of transcriptionfactors which are characterized by a distinct forkhead domain. Thisgene likely functions as a trigger for apoptosis through expressionof genes necessary for cell death. Translocation of this gene withthe MLL gene is associated with secondary acute leukemia.Alternatively spliced transcript variants encoding the same proteinhave been observed.
Zhuo de, X., et al. J. Biol. Chem. 285(41):31491-31501(2010)Tudzarova, S., et al. EMBO J. 29(19):3381-3394(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Mikse, O.R., et al. Cancer Res. 70(15):6205-6215(2010)Chen, J., et al. PLoS ONE 5 (8), E12293 (2010) :
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