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NOS2A Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P35228
Clone Names 80325167
Additional Information
Gene ID 4843
Other Names Nitric oxide synthase, inducible, Hepatocyte NOS, HEP-NOS, Inducible NO synthase, Inducible NOS, iNOS, NOS type II, Peptidyl-cysteine S-nitrosylase NOS2, NOS2, NOS2A
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOS2 (HGNC:7873)
Synonyms NOS2A
Function Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004, PubMed:7682706, PubMed:7504305). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109).
Cellular Location Cytoplasm, cytosol. Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization.
Tissue Location Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets Expressed in chondrocytes (PubMed:7504305)
Research Areas
Citations (0)
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Background

Nitric oxide is a reactive free radical which acts as abiologic mediator in several processes, including neurotransmissionand antimicrobial and antitumoral activities. This gene encodes anitric oxide synthase which is expressed in liver and is inducibleby a combination of lipopolysaccharide and certain cytokines. Threerelated pseudogenes are located within the Smith-Magenis syndromeregion on chromosome 17.

References

Ryk, C., et al. J. Urol. 184(5):2150-2157(2010)Planche, T., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299 (5), R1248-R1253 (2010) :Feng, C., et al. FEBS Lett. 584(20):4335-4338(2010)Mokrzycka, M., et al. Folia Histochem. Cytobiol. 48(2):191-196(2010)Tupitsyna, T.V., et al. Mol. Gen. Mikrobiol. Virusol. 3, 3-7 (2010) :

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$ 277.78
Cat# BP14168a
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