|Other Names||Nitric oxide synthase, inducible, Hepatocyte NOS, HEP-NOS, Inducible NO synthase, Inducible NOS, iNOS, NOS type II, Peptidyl-cysteine S-nitrosylase NOS2, NOS2, NOS2A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).|
|Tissue Location||Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets|
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Nitric oxide is a reactive free radical which acts as abiologic mediator in several processes, including neurotransmissionand antimicrobial and antitumoral activities. This gene encodes anitric oxide synthase which is expressed in liver and is inducibleby a combination of lipopolysaccharide and certain cytokines. Threerelated pseudogenes are located within the Smith-Magenis syndromeregion on chromosome 17.
Ryk, C., et al. J. Urol. 184(5):2150-2157(2010)Planche, T., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299 (5), R1248-R1253 (2010) :Feng, C., et al. FEBS Lett. 584(20):4335-4338(2010)Mokrzycka, M., et al. Folia Histochem. Cytobiol. 48(2):191-196(2010)Tupitsyna, T.V., et al. Mol. Gen. Mikrobiol. Virusol. 3, 3-7 (2010) :
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