|Other Names||Metal transporter CNNM2, Ancient conserved domain-containing protein 2, Cyclin-M2, CNNM2, ACDP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop|
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CNNM2 is a divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Takeuchi, F., et al. Circulation 121(21):2302-2309(2010)Yasuno, K., et al. Nat. Genet. 42(5):420-425(2010)Simon-Sanchez, J., et al. Nat. Genet. 41(12):1308-1312(2009)Newton-Cheh, C., et al. Nat. Genet. 41(6):666-676(2009)
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