ITGA8 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P53708 |
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Clone Names | 81202051 |
Gene ID | 8516 |
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Other Names | Integrin alpha-8, Integrin alpha-8 heavy chain, Integrin alpha-8 light chain, ITGA8 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ITGA8 |
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Function | Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. |
Cellular Location | Membrane; Single- pass type I membrane protein. Cell membrane |
Tissue Location | Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
References
Benoit, Y.D., et al. Biochem. Biophys. Res. Commun. 399(3):434-439(2010)Simon-Sanchez, J., et al. Nat. Genet. 41(12):1308-1312(2009)Benoit, Y.D., et al. Biol. Cell 101(12):695-708(2009)Sato, Y., et al. J. Biol. Chem. 284(21):14524-14536(2009)Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
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