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ITGA8 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P53708
Clone Names 81202051
Peptide ID 81202051
Additional Information
Gene ID 8516
Other Names Integrin alpha-8, Integrin alpha-8 heavy chain, Integrin alpha-8 light chain, ITGA8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGA8
Function Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Cellular Location Membrane; Single-pass type I membrane protein Cell membrane
Tissue Location Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
Research Areas
Citations (0)

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Background

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.

References

Benoit, Y.D., et al. Biochem. Biophys. Res. Commun. 399(3):434-439(2010)Simon-Sanchez, J., et al. Nat. Genet. 41(12):1308-1312(2009)Benoit, Y.D., et al. Biol. Cell 101(12):695-708(2009)Sato, Y., et al. J. Biol. Chem. 284(21):14524-14536(2009)Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :

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$ 80.00
Cat# BP14177c
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