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GNAQ Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P50148 |
|---|---|
| Clone Names | 90904140 |
| Gene ID | 2776 |
|---|---|
| Other Names | Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein alpha-q, GNAQ, GAQ |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GNAQ |
|---|---|
| Synonyms | GAQ |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long- chain fatty acids (LCFAs) (PubMed:27852822). Together with GNA11, required for heart development (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor. Golgi apparatus. Nucleus {ECO:0000250|UniProtKB:P21279} Nucleus membrane {ECO:0000250|UniProtKB:P21279}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250|UniProtKB:P21279} |
| Tissue Location | Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This locus encodes a guanine nucleotide-binding protein.The encoded protein, an alpha subunit in the Gq class, couples aseven-transmembrane domain receptor to activation of phospolipaseC-beta. Mutations at this locus have been associated with problemsin platelet activation and aggregation. A related pseudogene existson chromosome 2.
References
Dratviman-Storobinsky, O., et al. Invest. Ophthalmol. Vis. Sci. 51(12):6180-6182(2010)Crouthamel, M., et al. Mol. Pharmacol. 78(4):767-777(2010)Chillar, A., et al. Biochemistry 49(30):6365-6374(2010)Klenke, S., et al. Pharmacogenet. Genomics 20(8):476-484(2010)Salmanian, S., et al. Biochem. Biophys. Res. Commun. 395(4):577-582(2010)
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