|Other Names||Corepressor interacting with RBPJ 1, CBF1-interacting corepressor, Recepin, CIR1, CIR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1417b was selected from the C-term region of human CIR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.|
|Cellular Location||Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome|
|Tissue Location||Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
CIR may modulate splice site selection during alternative splicing of pre-mRNAs. It regulates transcription and acts as corepressor for RBPSUH. It recruits RBPSUH to the Sin3-histone deacetylase complex (HDAC), and is required for RBPSUH-mediated repression of transcription.
Olsen,J.V., Cell 127 (3), 635-648 (2006)Maita,H., Exp. Cell Res. 303 (2), 375-387 (2005)Zhou,S., Mol. Cell. Biol. 21 (18), 6222-6232 (2001)
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