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Mouse Camk2b Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P28652
Clone Names 110316068
Peptide ID 110316068
Additional Information
Gene ID 12323
Other Names Calcium/calmodulin-dependent protein kinase type II subunit beta, CaM kinase II subunit beta, CaMK-II subunit beta, Camk2b, Camk2d
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Camk2b
Synonyms Camk2d
Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Cellular Location Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side
Research Areas
Citations (0)

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CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).


Martinez-Pena y Valenzuela, I., et al. J. Neurosci. 30(37):12455-12465(2010)Jin, X.L., et al. Biol. Reprod. 82(2):459-468(2010)van Woerden, G.M., et al. Nat. Neurosci. 12(7):823-825(2009)Butcher, A.J., et al. J. Biol. Chem. 284(25):17147-17156(2009)Cheng, T.W., et al. Eur. J. Neurosci. 29(6):1083-1095(2009)

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$ 80.00
Cat# BP14185c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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