|Other Names||Heat shock factor protein 1, HSF 1, Heat shock transcription factor 1, HSTF 1, HSF1, HSTF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a heat-shock transcriptionfactor. Transcription of heat-shock genes is rapidly induced aftertemperature stress. Hsp90, by itself and/or associated withmultichaperone complexes, is a major repressor of this gene.
Hayashida, N., et al. EMBO J. 29(20):3459-3469(2010)Sangle, G.V., et al. Endocrinology 151(9):4455-4466(2010)Shunmei, E., et al. Mol. Cells 29(5):527-531(2010)Kim, S.A., et al. Int. J. Oncol. 36(4):867-872(2010)Wang, C., et al. J Transl Med 8, 44 (2010) :
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